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Table 2 Angiographic characteristics and treatment characteristics at first clinical ISR presentation

From: In-stent restenosis of drug-eluting stents: clinical presentation and outcomes in a real-world scenario

ParameterTotalACS cohortNon-ACS cohortP value
ISR characteristics(n = 210)(n = 129)(n = 81) 
ISR type   0.961
 I. Focal134 (63.8%)84 (65.1%)50 (61.7%) 
 II. Diffuse23 (11.0%)14 (10.9%)9 (11.1%)
 III. Proliferative10 (4.7%)6 (4.7%)4 (4.9%)
 IV. Complete43 (20.5%)25 (19.4%)18 (22.2%)
ISR vessel   0.203
 Left anterior descending112 (53.3%)62 (48.1%)50 (61.7%) 
 Left circumflex artery49 (23.3%)33 (25.6%)16 (19.8%) 
 Right coronary artery47 (22.4%)32 (24.8%)15 (18.5%) 
 Left main2 (1.0%)2 (1.6%)0 (0.0%) 
Proximal ISR location113 (53.8%)68 (52.7%)45 (55.6%)0.776
Disease burden(n = 191)(n = 118)(n = 73)0.715
 Single-vessel disease72 (37.7%)42 (35.6%)30 (41.1%) 
 Double-vessel disease67 (35.1%)42 (35.6%)25 (34.2%) 
 Triple-vessel disease52 (27.2%)34 (28.8%)18 (24.7%) 
Treatment plan(n = 191)(n = 118)(n = 73)0.620
 Medical therapy37 (19.4%)24 (20.3%)13 (17.8%) 
 CABG50 (26.2%)33 (28.0%)17 (23.3%) 
 PCI104 (54.5%)61 (51.7%)43 (58.9%) 
Details of PCI
 Procedural success101 (97.1%)59 (96.7%)42 (97.7%)1.000
 PCI type   0.082
  POBA21 (20.2%)16 (26.2%)5 (11.6%) 
  DCB11 (10.6%)4 (6.6%)7 (16.3%) 
  New DES72 (69.2%)41 (67.2%)31 (72.1%) 
   No. of stents1.14 ± 0.351.16 ± 0.371.12 ± 0.330.608
   Stent length29.7 ± 11.032.0 ± 12.926.4 ± 6.40.045
   Stent diameter3.03 ± 0.403.00 ± 0.363.08 ± 0.450.451
  Adjunct Devices
   Rotablation2 (1.9%)2 (3.3%)0 (0.0%)0.342
   Cutting or NC balloon24 (23.1%)13 (21.3%)11 (25.6%)0.390
   IVUS guidance25 (24.0%)13 (21.3%)12 (27.9%)0.292
  1. ACS acute coronary syndrome, CABG coronary artery bypass grafting, DCB drug-coated balloon, DES drug-eluting stent, IVUS intravascular ultrasound, ISR in-stent restenosis, NC non-compliant, PCI percutaneous coronary intervention, POBA plain old balloon angioplasty