Colchicine ameliorates the chronic inflammatory state in patients with chronic rheumatic valvular heart disease: a pilot study

The Egyptian Heart Journal

Table 4 Effect of colchicine on the serum IL-6 and CRP in relation to different penicillin regimens

		Penicillin timing (days)			Test value	P value*	Sig.
		15	21	30	Test value	P value*	Sig.
CRP level before starting colchicine (IU/ml)	Mean ± SD	4.80 ± 4.51	5.36 ± 3.56	11.00 ± 2.45	5.909	0.007	HS
CRP level before starting colchicine (IU/ml)	Range	0–12	0–12	6–12	5.909	0.007	HS
CRP level after 1 month of regular colchicine intake (IU/ml)	Mean ± SD	2.20 ± 2.65	3.00 ± 2.63	7.00 ± 2.45	7.435	0.002	HS
	Range	0–6	0–6	6–12	7.435	0.002	HS
IL-6 level before starting colchicine (ng/L)	Mean ± SD	98.67 ± 32.15	117.50 ± 42.73	141.67 ± 14.72	3.373	0.047	S
IL-6 level before starting colchicine (ng/L)	Range	30–145	40–160	120–160	3.373	0.047	S
IL-6 level after 1 month of regular colchicine intake (ng/L)	Mean ± SD	36.67 ± 11.75	49.29 ± 22.26	59.17 ± 25.58	3.423	0.045	S
	Range	25–60	25–100	35–100	3.423	0.045	S

CRP C-reactive protein, IL-6 interleukin-6, SD standard deviation
*P value between the 15-, 21-, and 30-day regimens of long acting penicillin. HS = P value < 0.0001. S = P value < 0.001