Skip to main content

Table 4 Effect of colchicine on the serum IL-6 and CRP in relation to different penicillin regimens

From: Colchicine ameliorates the chronic inflammatory state in patients with chronic rheumatic valvular heart disease: a pilot study

  Penicillin timing (days) Test value P value* Sig.
15 21 30
CRP level before starting colchicine (IU/ml) Mean ± SD 4.80 ± 4.51 5.36 ± 3.56 11.00 ± 2.45 5.909 0.007 HS
Range 0–12 0–12 6–12
CRP level after 1 month of regular colchicine intake (IU/ml) Mean ± SD 2.20 ± 2.65 3.00 ± 2.63 7.00 ± 2.45 7.435 0.002 HS
Range 0–6 0–6 6–12
IL-6 level before starting colchicine (ng/L) Mean ± SD 98.67 ± 32.15 117.50 ± 42.73 141.67 ± 14.72 3.373 0.047 S
Range 30–145 40–160 120–160
IL-6 level after 1 month of regular colchicine intake (ng/L) Mean ± SD 36.67 ± 11.75 49.29 ± 22.26 59.17 ± 25.58 3.423 0.045 S
Range 25–60 25–100 35–100
  1. CRP C-reactive protein, IL-6 interleukin-6, SD standard deviation
  2. *P value between the 15-, 21-, and 30-day regimens of long acting penicillin. HS = P value < 0.0001. S = P value < 0.001