Table 3 Clinical presentation

Number of patients

1645

914

249

409

73

HF: new onset, %

38.0

39.2

29.5

42.1

28.6

0.004

HF: worsening, %

62.0

60.8

70.5

58.0

71.4

0.004

NYHA functional class III or IV

92.8

91.4

90.8

96.6

97.2

0.002

HR, median, IQR

100 (90–112)

104 (94–116)

90 (80–105)

100 (90–110)

100 (80–110)

< 0.0001

SBP median, IQR

130 (110–150)

140 (120–164)

115 (110–130)

120 (100–140)

110 (100–130)

< 0.0001

Sodium, mean (± SD)

137.1 (± 6.3)​

138.3 (± 5.9)

134.6 (± 6.2)

136.2 (± 5.8)

132.9 (± 7.4)

< 0.001

 Cardiogenic shock/HF

3.7

2.3

4.1

6.1

7.0

< 0.0001

 ACS/HF

19.6

26.6

9.8

12.2

5.6

< 0.0001

 Decompensated HF

54.8

47.1

68.2

61.1

71.8

0.15

 Hypertensive HF

4.7

5.6

4.1

3.4

1.4

0.16

 Pulmonary edema/HF

12.7

12.4

9.4

15.2

14.1

 Right-sided HF

4.5

6.0

4.5

2.0

0

0.005