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Table 1 Characteristics of each study included in the final analysis

From: The role of NKX2-5 gene polymorphisms in congenital heart disease (CHD): a systematic review and meta-analysis

Serial no Authors Year Country Gender wise distribution (M/F) SOC Sample size Genotyping NOS score
Cases (N) Controls (N)
1 Behiry 2019 Egypt 44% = M
56% = F
PB 150 90 PCR-Sequencing 8
2 Peng 2010 China NA PB 135 114 PCR-Sequencing 7
3 Cao 2015 China 29 = M
41 = F
HB 70 136 PCR-Sequencing 7
4 Ketharnathan 2015 India 26 = M
24 = F
PB 50 50 PCR-Sequencing/RT-PCR 8
5 Pang 2012 China 110 = M
103 = F
HB 213 194 PCR-Sequencing 8
6 Dinesh 2010 India NA PB 150 70 PCR-Sequencing 7
7 Ouyang 2011 China NA PB 125 105 PCR-Sequencing 7
8 Wang et al. 2019 China 157 = M
282 = F
PB 439 567 Multiplex PCR, qPCR, Sequencing 8
9 Liu [1] 2009 China NA PB 160 200 PCR-Sequencing 7
10 Liu [2] 2009 China NA PB 180 200 PCR-Sequencing 7
11 Han 2011 China NA   81 52   7
12 Xie 2013 China 71 = M
65 = F
PB 136 200 PCR-Sequencing  
13 Xiong 2013 China 166 = M
58 = F
PB 224 121 PCR, DHPLC-Sequencing 7
14 Yin 2018 China 59 = M
39 = F
PB 98 200 PCR-direct sequence analysis 8
15 Zhang 2009 China 132 = M
98 = F
PB 230 200 PCR, denaturing high-performance liquid chromatography, and sequencing 8
16 Zhao 2020 China NA HB 620 620 PCR, MassARRAY system 8
17 Shi 2005 China NA NA 110 110 –– 8