From: Switching from warfarin to direct-acting oral anticoagulants: it is time to move forward!
 | Apixaban | Rivaroxaban | Betrixaban |
---|---|---|---|
Onset | 3–4 h | Rapid | Rapid |
Protein binding | 87% | 92–95% | 60% |
Metabolism | Hepatic; predominantly 3A4 Substrate of P-gp | Hepatic; predominantly 3A4 Substrate of P-gp | Minimal hepatic metabolism Substrate of P-gp |
Bioavailability | 50% | 66–100% | 34% |
Elimination half-life | 2.5 mg ~ 8 h 5 mg ~ 15 h | 5–9 h | 37 h |
Excretion | Urine ~ 27% as parent drug Feces ~ 25% as metabolites | Urine 36% as unchanged drug | Biliary system ~ 85% as unchanged drug Urine < 8% |