Chronic activation of cardiac Atg-5 and pancreatic Atg-7 by intermittent fasting alleviates acute myocardial infarction in old rats

The Egyptian Heart Journal

Table 1 Anthropometric measures, visceral fat, glucose homeostasis parameters and pancreatic Atg-7 in the four study groups

	Adult (10)	Old (6)	Old-ISO (7)	Old-F-ISO (7)
BW_i (g)	198.50 ± 7.95	366.66 ± 15.95^a	353.57 ± 17.75^a	376.42 ± 16.57^a
BW_f (g)	217 ± 16.07	344.16 ± 19.51^a	331.42 ± 20.16^a	295 ± 14.67^a
% BW (%)	8.85 ± 5.21	− 6.30 ± 2.40^a	− 6.21 ± 3.35^a	− 20.77 ± 5.26^a,b.c
BMI_i (g/cm²)	0.50 ± 0.02	0.62 ± 0.03^a	0.61 ± 0.03^a	0.67 ± 0.02^a,c
BMI_f (g/cm²)	0.53 ± 0.02	0.63 ± 0.03^a	0.62 ± 0.04^a	0.57 ± 0.01
% BMI (%)	5.23 ± 3.13	0.48 ± 2.63	0.69 ± 3.33	− 15.44 ± 2.30^a,b,c
WC_i (cm)	14.50 ± 0.26	18.33 ± 0.33^a	18.57 ± 0.44^a	18.07 ± 0.25^a
WC_f (cm)	13.20 ± 0.48	16.25 ± 0.70^a	16.64 ± 0.47^a	15.07 ± 0.56^a
% WC	− 8.93 ± 2.93	− 11.48 ± 2.77	− 9.99 ± 3.74	− 16.54 ± 3.21
VATW (mg)	2937.00 ± 414.72	3311.67 ± 719.35	3414.29 ± 794.71	275.71 ± 184.62^a,b,c
VATW/BW(mg/gm)	13.27 ± 1.00	9.48 ± 1.88	10.05 ± 2.28	0.87 ± 0.59^a,b,c

Data are expressed as mean ± SEM
Number in parenthesis is the number of rats in each group
i, initial; f, final; % percentage change; BW, body weight; BMI, body mass index; WC, waist circumference; VTW, visceral tissue weight; VTW/BW; visceral tissue weight/body weight; FPG, fasting plasma glucose; FI, fasting insulin; HOMA-IR, homeostatic model assessment of insulin resistance; HOMA-%B, homeostatic model assessment of beta cell function
^aSignificance of difference from adult group by LSD test at P < 0.05
^bSignificance of difference from old group by LSD test at P < 0.05
^cSignificance of difference from old-ISO group by LSD test at P < 0.05