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The Egyptian Heart Journal

Table 3 QTc interval comparison between different trastuzumab cycles using t-test of paired samples

From: Effects of trastuzumab and trastuzumab emtansine on corrected QT interval and left ventricular ejection fraction in patients with metastatic (HER2+) breast cancer

Trastuzumab

Results of QTc interval comparison using t-test of paired samples

QTc1 versus QTc2

QTc1 449.4 (23.26)

QTc2 452.4 (20.73)

t = − 3.25

df = 25

p = 0.003

QTc1 versus QTc3

QTc1 449.4 (23.26)

QTc3 455.1 (21.08)

t = − 6.19

df = 25

p < 0.001

QTc1 versus QTc4

QTc1 449.4 (23.26)

QTc4 472.1 (32.08)

t = − 6.19

df = 25

p < 0.001

QTc1 versus QTc5

QTc1 449.4 (23.26)

QTc5 473 (27.79)

t = − 7.96

df = 25

p < 0.001

QTc1 versus QTc6

QTc1 449.4 (23.26)

QTc6 471.3 (28.58)

t = − 6.5

df = 25

p < 0.001

QTc1 versus QTc7

QTc1 449.4 (23.26)

QTc7 453 (20.42)

t = − 3.57

df = 25

p = 0.001

QTc2 versus QTc3

QTc2 452.4 (20.73)

QTc3 455.1 (21.08)

t = − 3.87

df = 25

p < 0.001

QTc2 versus QTc4

QTc2 452.4 (20.73)

QTc4 472.1 (32.08)

t = − 5.02

df = 25

p < 0.001

QTc2 versus QTc5

QTc2 452.4 (20.73)

QTc5 473 (27.79)

t = − 6.67

df = 25

p < 0.001

QTc2 versus QTc6

QTc2 452.4 (20.73)

QTc6 471.3 (28.58)

t = − 5.42

df = 25

p < 0.001

QTc2 versus QTc7

QTc2 452.4 (20.73)

QTc7 453 (20.42)

t = − 0.67

df = 25

p = 0.507

QTc3 versus QTc4

QTc3 455.1 (21.08)

QTc4 472.1 (32.08)

t = − 4.29

df = 25

p < 0.001

QTc3 versus QTc5

QTc3 455.1 (21.08)

QTc5 473 (27.79)

t = − 5.84

df = 25

p < 0.001

QTc3 versus QTc6

QTc3 455.1 (21.08)

QTc6 471.3 (28.58)

t = − 4.67

df = 25

p < 0.001

QTc3 versus QTc7

QTc3 455.1 (21.08)

QTc7 453 (20.42)

t = 1.91

df = 25

p = 0.067

QTc4 versus QTc5

QTc4 472.1 (32.08)

QTc5 473 (27.79)

t = − 0.78

df = 25

p = 0.443

QTc4 versus QTc6

QTc4 472.1 (32.08)

QTc6 471.3 (28.58)

t = 0.59

df = 25

p = 0.556

QTc4 versus QTc7

QTc4 472.1 (32.08)

QTc7 453 (20.42)

t = 4.71

df = 25

p = 0.556

QTc5 versus QTc6

QTc5 473 (27.79)

QTc6 471.3 (28.58)

t = 1.96

df = 25

p = 0.061

QTc5 versus QTc7

QTc5 473 (27.79)

QTc7 453 (20.42)

t = 6.17

df = 25

p < 0.001

QTc6 versus QTc7

QTc6 471.3 (28.58)

QTc7 453 (20.42)

t = 5.01

df = 25

p < 0.001

  1. Student's t-test of paired samples was also used to compare QTc interval values obtained before each trastuzumab emtansine cycle and after the last application of the drug. A statistically significant p value of < 0.05 was used
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