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The Egyptian Heart Journal

Table 4 QT interval comparison between trastuzumab emtansine cycles using t-test of paired samples

From: Effects of trastuzumab and trastuzumab emtansine on corrected QT interval and left ventricular ejection fraction in patients with metastatic (HER2+) breast cancer

Trastuzumab emtansine

Results of QTc interval comparison using t-test of paired samples

QTc1 versus QTc2

QTc1 448.6 (18.52)

QTc2 453.6 (18.44)

t = − 7.28

df = 23

p < 0.001

QTc1 versus QTc3

QTc1 448.6 (18.52)

QTc3 458.3 (19.19)

t = − 9.34

df = 23

p < 0.001

QTc1 versus QTc4

QTc1 448.6 (18.52)

QTc4 470.1 (26.72)

t = − 6.12

df = 23

p < 0.001

QTc1 versus QTc5

QTc1 448.6 (18.52)

QTc5 474.5 (28.95)

t = − 6.78

df = 23

p < 0.001

QTc1 versus QTc6

QTc1 448.6 (18.52)

QTc6 471.9 (25.56)

t = − 6.69

df = 23

p < 0.001

QTc1 versus QTc7

QTc1 448.6 (18.52)

QTc7 454.4 (16.91)

t = − 4.54

df = 23

p < 0.001

QTc2 versus QTc3

QTc2 453.6 (18.44)

QTc3 458.3 (19.19)

t = − 5.43

df = 23

p < 0.001

QTc2 versus QTc4

QTc2 453.6 (18.44)

QTc4 470.1 (26.72)

t = − 5.43

df = 23

p < 0.001

QTc2 versus QTc5

QTc2 453.6 (18.44)

QTc5 474.5 (28.95)

t = − 5.78

df = 23

p < 0.001

QTc2 versus QTc6

QTc2 453.6 (18.44)

QTc6 471.9 (25.56)

t = − 5.54

df = 23

p < 0.001

QTc2 versus QTc7

QTc2 453.6 (18.44)

QTc7 454.4 (16.91)

t = − 0.58

df = 23

p = 0.56

QTc3 versus QTc4

QTc3 458.3 (19.19)

QTc4 470.1 (26.72)

t = − 3.7

df = 23

p = 0.001

QTc3 versus QTc5

QTc3 458.3 (19.19)

QTc5 474.5 (28.95)

t = − 4.62

df = 23

p < 0.001

QTc3 versus QTc6

QTc3 458.3 (19.19)

QTc6 471.9 (25.56)

t = − 4.29

df = 23

p < 0.001

QTc3 versus QTc7

QTc3 458.3 (19.19)

QTc7 454.4 (16.91)

t = 3.13

df = 23

p = 0.005

QTc4 versus QTc5

QTc4 470.1 (26.72)

QTc5 474.5 (28.95)

t = − 4.63

df = 23

p < 0.001

QTc4 versus QTc6

QTc4 470.1 (26.72)

QTc6 471.9 (25.56)

t = − 1.59

df = 23

p = 0.124

QTc4 versus QTc7

QTc4 470.1 (26.72)

QTc7 454.4 (16.91)

t = 4.62

df = 23

p < 0.001

QTc5 versus QTc6

QTc5 474.5 (28.95)

QTc6 471.9 (25.56)

t = 2.09

df = 23

p = 0.047

QTc5 versus QTc7

QTc5 474.5 (28.95)

QTc7 454.4 (16.91)

t = 5.33

df = 23

p < 0.001

QTc6 versus QTc7

QTc6 471.9 (25.56)

QTc7 454.4 (16.91)

t = 5.27

df = 23

p < 0.001

  1. Student’s t-test of paired samples was also used to compare QTc interval values obtained before each trastuzumab emtansine cycle and after the last application of the drug. A statistically significant p value of < 0.05 was used
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