Left atrial appendage morphofunctional indices could be predictive of arrhythmia recurrence post-atrial fibrillation ablation: a meta-analysis

Papathanasiou, Konstantinos A.; Vrachatis, Dimitrios A.; Kazantzis, Dimitrios; Kossyvakis, Charalampos; Giotaki, Sotiria G.; Deftereos, Gerasimos; Raisakis, Konstantinos; Kaoukis, Andreas; Avramides, Dimitrios; Lambadiari, Vaia; Siasos, Gerasimos; Deftereos, Spyridon

doi:10.1186/s43044-023-00356-3

The Egyptian Heart Journal

Table 1 Studies main characteristics

From: Left atrial appendage morphofunctional indices could be predictive of arrhythmia recurrence post-atrial fibrillation ablation: a meta-analysis

Author/Year	Country	Study type	N	AFCA type	AF type	FU	Age (years)	Female (%)	HF (%)	LAA indices
Tsao [16]	Taiwan	R	68	RF	PAF, Per-AF	228 ± 79 d	53.3 ± 9.0	23.5	N/R	LAAEF
Park [27]	Korea	R	264	RF	PAF, Per-AF	33.2 ± 12.4 mo	54.8 ± 10.8	19.7	16.28	LAAV LAAEF
Machino-Ohtsuka [38]	Japan	R	123	RF	Per-AF	18 ± 2.3 mo	60 ± 9	15	N/R	LAAeV
Yoshida [43]	Japan	R	67	RF	PAF, Per-AF	6 mo	64 ± 8	13.43	N/R	LAAeV
Combes [44]	France	P	40	RF	Per-AF	12 mo	60 ± 11	15	N/R	LAAeV
Kim 2014	Korea	R	130	RF	Per-AF	33 mo (24–52)⁺	54.6 ± 9.3	13.84	30	LAAEF
Gerede [45]	Turkey	P	51	CB	PAF	12mo	54.6 ± 10.4	50.9	23.5	LAAeV
Fukushima [46]	Japan	P	105	RF	PAF	19 mo( 6–38)⁺	57 ± 12	23.5	N/R	LAAeV
Ariyama [47]	Japan	R	41	RF	NPAF	12 mo	58 ± 10	7	9.75	LAAeV
Ma [48]	China	P	120	RF	PAF, Per-AF	12 mo	64 ± 7	40	8.3	LAAeV
Nakatani [20]	Japan	R	126	RF	PAF, Per-AF	12 mo	62 ± 11	22	15	LAAeV
E Gul [18]	Canada	R	59	RF	PeAF	13 mo (4–67)⁺	64.6 ± 9.8	56	N/R	LAAV LAA_m
Zheng [19]	China	P	62	RF	PAF, Per-AF	N/R	N/R	N/R	N/R	LAAV
Shiozawa [17]	Japan	P	77	RF	PAF, Per-AF	580 ± 255 d	59 ± 8	19.48	N/R	LAAV LAAeV LAAOA LAA_m
Pinto Teixeira [21]	Portugal	P	52	RF	PAF, Per-AF	305.9 ± 144.6 d	54 ± 10	42	N/R	LAAV
Nedios [22]	Germany	R	104	RF	PAF, Per-AF	26 ± 14 mo	58 ± 10	31	5.76	LAAV
He [23]	China	P	80	RF	PAF	12 mo	57.31 ± 10.42	40	20	LAAeV LAAEF
Kocyigit [24]	Turkey	P	359	CB	PAF, Per-AF	37 mo (17–60)⁺	56.41 ± 7.88	49.42	N/R	LAAOA LAA_m
Du [25]	China	R	108	RF	PAF, Per-AF	12 mo	63.1 ± 8.1	46.3	N/R	LAAV LAAOA
Tian [26]	China	R	83	RF	PAF, Per-AF	19 mo (4–24)⁺	60.36 ± 10.11	40.9	21.6	LAAV LAAEF
Yang 2020	China	P	215	RF	Per-AF	R( +): 4 mo (3–5)⁺ R(-): 6 mo (6–6)⁺	R( +) 62.9 ± 9.4 R(-) 62.8 ± 9.6	R( +)16.4 R(-) 26.3	N/R	LAAeV
Wei [29]	China	P	150	RF	PAF, Per-AF	14 mo⁺	64 ± 11	45.3	12.6	LAAeV
Straube [30]	Germany	R	473	CB	PAF, Per-AF	19 mo⁺	66.2 ± 9.5	40	N/R	LAAV LAAOA LAA_m
Gong [31]	China	R	84	RF	PAF, Per-AF	618.6 d	R( +) 67.5 ± 7.5 R(-) 66.1 ± 9.0	30.95	N/R	LAAeV LAA_m
Yang [28, 32]	China	R	164	RF	Per-AF	15 mo (12–18)⁺	58.2 ± 9.7	23.17	9.8	LAAeV
You [33]	China	R	238	RF, CB, RF + CB	PAF	48 mo⁺	59.37 ± 11.0	45.4	5.9	LAAeV
Istratoaie [34]	Romania	P	81	RF	PAF	12 mo (11–14)⁺	55.3 ± 9	40.7	N/R	LAAeV
Ma [35]	China	R	124	RF	PAF, Per-AF	12 ± 3 mo	R( +) 65.5 ± 6 R(-) 62.6 ± 7.3	R( +)31.7 R(-) 41.4	N/R	LAAeV
Kielbasa 2021	Poland	R	417	CB	PAF	24 mo (15.5–45.6)⁺	59 (mean)	39.3	3.1	LAAeV
Kim [37]	Korea	R	992	RF	PAF, Per-AF	36 mo	55.8 ± 10.5	20.4	4	LAAV
Kim [39]	Korea	R	3.120	RF	PAF, Per-AF	36 mo	55.74 ± 10.96	21.1	9.4	LAAeV
Spittler [40]	Germany	R	134	RF	Per-AF	19.6 ± 14.6 mo	63.8 ± 10.2	36.6	N/R	LAAeV
Simon [41]	Hungary	R	561	RF	PAF, Per-AF	recurrence-free time 22.7 mo⁺	61.9 ± 10.2	34.9	12.7	LAAV LAAeV LAAOA
Szegedi [42]	Hungary	R	428	RF	PAF	8.8–43 mo	60.7 ± 10.8	35.5	6.1	LAA_m

⁺ = median, R( +) = recurrence, R(-) = no recurrence, N/R not reported, PAF paroxysmal atrial fibrillation, Per-AF persistent atrial fibrillation, NPAF non-paroxysmal atrial fibrillation, AFCA atrial fibrillation catheter ablation, RF radiofrequency ablation, CB cryoablation, FU follow-up, N study population, R retrospective, P prospective, mo months, d days, HF heart failure, LAA left atrial appendage, LAAV LAA volume, LAAeV LAA emptying velocity, LAAOA LAA orifice area, LAAEF LAA ejection fraction, LAA_m LAA morphology, chicken wing versus non-chicken wing

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