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The Egyptian Heart Journal

Table 1 Major and minor criteria for high bleeding risk

From: Boosting protection for patients with non-acute cardiovascular disease: a focus on antithrombotic regimen (a consensus expert opinion from the Egyptian Society of Cardiology working group of thrombosis and prevention)

Major

Minor

 

Age ≥ 75 years

Anticipated use of long-term oral anticoagulation

 

Severe or end-stage CKD (eGFR < 30 mL/min)

Moderate CKD (eGFR 30–59 mL/min)

Hemoglobin < 11 g/dL

Hemoglobin 11–12.9 g/dL for men and 11–11.9 g/dL for women

Spontaneous bleeding requiring hospitalization or transfusion in the past 6 months or at any time, if recurrent

Spontaneous bleeding requiring hospitalization or transfusion within the past 12 months not meeting the major criterion

Moderate or severe baseline thrombocytopenia (platelet count < 100 × 109/L)

 

Chronic bleeding diathesis

 

Liver cirrhosis with portal hypertension

 
 

Long-term use of oral NSAIDs or steroids

Active malignancy* (excluding nonmelanoma skin cancer) within the past 12 months

 

Previous spontaneous ICH (at any time)

Any ischemic stroke at any time not meeting the major criterion

Previous traumatic ICH within the past 12 months

Presence of a bAVM

Moderate or severe ischemic strokeâ—Š within the past 6 months

Nondeferrable major surgery on DAPT

 

Recent major surgery or major trauma within 30 days

 
  1. CKD chronic kidney disease, eGFR estimated glomerular filtration rate, NSAID nonsteroidal anti-inflammatory drug, ICH intracranial hemorrhage, bAVM brain arteriovenous malformation, DAPT dual antiplatelet therapy, PCI percutaneous coronary intervention
  2. *Active malignancy is defined as diagnosis within 12 months and/or ongoing requirement for treatment (including surgery, chemotherapy, or radiotherapy)
  3. ◊National Institutes of Health Stroke Scale score ≥ 5
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