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Table 1 Comparing surface ECG and Holter monitoring variables at baseline and after completion of treatment

From: Assessing the impact of a combination of sofosbuvir and daclatasvir treatment for hepatitis C virus infection on heart rate, rhythm and heart rate variability using 24-hour ECG monitoring

Variable

Baseline (n = 50)

After completion of treatment (n = 50)

p value

Surface ECG

PR interval, ms

154 ± 25.95

151.4 ± 23.82

0.124

QTc interval, ms

397.34 ± 29.38

395.04 ± 30.23

0.403

24-h ECG (Holter) monitoring

Minimum heart rate, bpm

55.88 ± 9.2

56.66 ± 9.45

0.457

Maximum heart rate, bpm

129.08 ± 20.07

128.98 ±16.89

0.964

Average heart rate, bpm

79.44 ±10.14

79.96 ± 8.77

0.534

Patients with significant pauses, n (%)

0 (0%)

0 (0%)

1

Patients with sinus tachycardia episodes, n (%)

47 (94%)

47 (94%)

1

Patients with sinus bradycardia episodes, n (%)

35 (70%)

33 (66%)

0.83

Patients with PACs, n (%)

6 (12%)

3 (6%)

0.485

Patients with PVCs, n (%)

22 (44%)

14 (28%)

0.145

  1. Continuous variables are expressed as mean and standard deviation, whereas categorical variables are expressed as number (percentage)
  2. QTc interval corrected QT interval, PACs premature atrial contraction, PVCs premature ventricular contractions