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Table 3 Conventional 2D and 3D echocardiographic data of the study patients in the baseline and follow-up visits

From: The combined role of NT-proBNP and LV-GLS in the detection of early subtle chemotherapy-induced cardiotoxicity in breast cancer female patients

Parameters

Baseline (mean± SD)

FU (mean± SD)

P value

M-Mode LVEF (%)

64.6 ± 5.60

62.5 ± 6.98

0.028

LVFS (%)

35.3 ± 4.83

34.12 ± 5.80

0.174

LVDD (cm)

4.5 ± 0.53

4.61 ± 0.60

0.103

LVSD (cm)

2.91 ± 0.40

3.54 ± 4.12

0.189

SWT (cm)

0.84 ± 0.11

0.83 ± 0.11

0.584

PWT (cm)

0.9 ± 0.10

0.9 ± 0.11

0.887

2D volumes

   

 LVEDV (ml)

62.51±17.10

64.7±17.81

0.373

 LVESV (ml)

23.8±6.93

26.2±8.14

0.029

 LVEF (%)

61.7±5.10

60.32±5.60

0.115

 Mean delta 2D LVEF (%)

− 1.4±7.3

 LAVI (mL/m2)

20.24±5.44

19.21±4.50

0.052

Diastolic function

   

 E (cm/s)

0.8±0.17

1.71±7.9

0.323

 A (cm/s)

0.65±0.21

0.7±0.17

0.365

 E/A ratio

1.32±0.39

1.24±0.39

0.049

 EDT (ms)

182.14±33.99

183.1±23.20

0.839

 S TDI MV (cm/s)

11.7 ±9.15

10.9±1.90

0.435

 E’ (cm/s)

11.65 ±3.13

11.7±3.05

0.924

 A’ (cm/s)

9.31 ±3.10

10.12±2.62

0.028

 E/E’ ratio

6.96±2.40

6.9±2.40

0.823

 Tei index

0.31±0.10

0.34±0.10

0.014

RV function

   

 TAPSE (cm)

2.5±0.49

2.8±0.47

<0.001

 FAC (%)

51.51±7.73

51.3±7.90

0.808

 PASP mmHg

3.44±8.10

3.5±8.04

0.873

 S-TDI TV (cm/s)

13.23 ±2.03

13.75±2.02

0.027

 RVOT (cm)

1.7±0.40

1.7±0.32

0.570

 CS (cm)

0.72±0.15

0.73±0.12

0.572

 IVC (cm)

1.4 ±0.33

1.41 ±0.29

0.959

3D Echocardiography

   

 LVEDV (mL)

74.34±15.14

75.94 ±18.99

0.523

 LVESV (mL)

28.13±6.32

30.38±9.05

0.037

 EF (%)

61.84 ±5.79

59.88±5.42

0.031

 Mean delta 3D LVEF (%)

− 2.0 ± 7.4

  1. LVEF left ventricular ejection fraction, LVFS left ventricular fractional shortening, LVDD left ventricular diastolic dimension, LVSD left ventricular systolic dimension, SWT septal wall thickness, PWT posterior wall thickness, 2D 2 dimensional, LVEDV left ventricular end diastolic volumes, LVESV left ventricular end systolic volumes, LAVI left atrium volume indexed, EDT E deceleration time, TDI tissue Doppler imaging, MV mitral valve, RV right ventricle, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, PASP pulmonary artery systolic pressure, TV tricuspid valve, RVOT right ventricular outflow tract, CS coronary sinus, IVC inferior vena cava