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Table 3 Conventional 2D and 3D echocardiographic data of the study patients in the baseline and follow-up visits

From: The combined role of NT-proBNP and LV-GLS in the detection of early subtle chemotherapy-induced cardiotoxicity in breast cancer female patients

Parameters Baseline (mean± SD) FU (mean± SD) P value
M-Mode LVEF (%) 64.6 ± 5.60 62.5 ± 6.98 0.028
LVFS (%) 35.3 ± 4.83 34.12 ± 5.80 0.174
LVDD (cm) 4.5 ± 0.53 4.61 ± 0.60 0.103
LVSD (cm) 2.91 ± 0.40 3.54 ± 4.12 0.189
SWT (cm) 0.84 ± 0.11 0.83 ± 0.11 0.584
PWT (cm) 0.9 ± 0.10 0.9 ± 0.11 0.887
2D volumes    
 LVEDV (ml) 62.51±17.10 64.7±17.81 0.373
 LVESV (ml) 23.8±6.93 26.2±8.14 0.029
 LVEF (%) 61.7±5.10 60.32±5.60 0.115
 Mean delta 2D LVEF (%) − 1.4±7.3
 LAVI (mL/m2) 20.24±5.44 19.21±4.50 0.052
Diastolic function    
 E (cm/s) 0.8±0.17 1.71±7.9 0.323
 A (cm/s) 0.65±0.21 0.7±0.17 0.365
 E/A ratio 1.32±0.39 1.24±0.39 0.049
 EDT (ms) 182.14±33.99 183.1±23.20 0.839
 S TDI MV (cm/s) 11.7 ±9.15 10.9±1.90 0.435
 E’ (cm/s) 11.65 ±3.13 11.7±3.05 0.924
 A’ (cm/s) 9.31 ±3.10 10.12±2.62 0.028
 E/E’ ratio 6.96±2.40 6.9±2.40 0.823
 Tei index 0.31±0.10 0.34±0.10 0.014
RV function    
 TAPSE (cm) 2.5±0.49 2.8±0.47 <0.001
 FAC (%) 51.51±7.73 51.3±7.90 0.808
 PASP mmHg 3.44±8.10 3.5±8.04 0.873
 S-TDI TV (cm/s) 13.23 ±2.03 13.75±2.02 0.027
 RVOT (cm) 1.7±0.40 1.7±0.32 0.570
 CS (cm) 0.72±0.15 0.73±0.12 0.572
 IVC (cm) 1.4 ±0.33 1.41 ±0.29 0.959
3D Echocardiography    
 LVEDV (mL) 74.34±15.14 75.94 ±18.99 0.523
 LVESV (mL) 28.13±6.32 30.38±9.05 0.037
 EF (%) 61.84 ±5.79 59.88±5.42 0.031
 Mean delta 3D LVEF (%) − 2.0 ± 7.4
  1. LVEF left ventricular ejection fraction, LVFS left ventricular fractional shortening, LVDD left ventricular diastolic dimension, LVSD left ventricular systolic dimension, SWT septal wall thickness, PWT posterior wall thickness, 2D 2 dimensional, LVEDV left ventricular end diastolic volumes, LVESV left ventricular end systolic volumes, LAVI left atrium volume indexed, EDT E deceleration time, TDI tissue Doppler imaging, MV mitral valve, RV right ventricle, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, PASP pulmonary artery systolic pressure, TV tricuspid valve, RVOT right ventricular outflow tract, CS coronary sinus, IVC inferior vena cava