Skip to main content

Table 2 Summary of the outcomes of interest

From: Direct comparison of non-vitamin K antagonist oral anticoagulant versus warfarin for stroke prevention in non-valvular atrial fibrillation: a systematic review and meta-analysis of real-world evidences

Outcomes NOACs (n) Warfarin (n) Model HR 95% CI p value of heterogeneity p value of Begg’s test p value of Egger’s test p
Lower limit Upper limit
Stroke
Apixaban 256909 474732 Random 0.73 0.64 0.84 < 0.01 0.77 0.77 < 0.01
Dabigatran 345545 365144 Random 0.87 0.81 0.94 < 0.01 0.70 0.78 < 0.01
Edoxaban 46035 78185 Fixed 0.67 0.60 0.76 0.84 1.00 0.46 < 0.01
Rivaroxaban 336406 486587 Random 0.81 0.73 0.90 < 0.01 0.19 0.41 < 0.01
All NOACs 984895 1604648 Random 0.77 0.69 0.87 < 0.01 0.73 0.85 < 0.01
All-cause mortality
Apixaban 95097 309813 Random 0.69 0.49 0.98 < 0.01 1.00 0.60 0.04
Dabigatran 216235 390118 Random 0.67 0.57 0.80 < 0.01 0.35 0.06 < 0.01
Edoxaban 16210 16785 Random 0.52 0.31 0.85 0.02 1.00 0.53 0.01
Rivaroxaban 128600 310114 Random 0.91 0.70 1.18 < 0.01 0.76 0.89 0.47
All NOACs 456142 1026830 Fixed 0.71 0.63 0.81 0.14 0.31 0.08 < 0.01
Major bleeding
Apixaban 234818 314596 Random 0.57 0.53 0.63 < 0.01 0.42 0.20 < 0.01
Dabigatran 292539 382810 Random 0.75 0.67 0.83 < 0.01 0.27 0.15 < 0.01
Edoxaban 48875 81025 Random 0.55 0.45 0.66 0.09 0.71 0.27 < 0.01
Rivaroxaban 337030 377026 Random 0.90 0.82 0.98 < 0.01 0.38 0.06 0.01
All NOACs 913262 1155457 Random 0.68 0.54 0.86 < 0.01 0.73 0.63 < 0.01
Intracranial bleeding
Apixaban 251901 442439 Random 0.57 0.48 0.68 < 0.01 0.71 0.06 < 0.01
Dabigatran 323015 488790 Random 0.44 0.38 0.52 < 0.01 1.00 0.14 < 0.01
Edoxaban 48875 81025 Random 0.44 0.26 0.76 < 0.01 1.00 0.06 < 0.01
Rivaroxaban 326289 439920 Fixed 0.69 0.64 0.74 0.14 0.08 0.07 < 0.01
All NOACs 950080 1452174 Random 0.54 0.42 0.70 < 0.01 0.73 0.26 < 0.01
Gastrointestinal bleeding
Apixaban 242813 401123 Random 0.58 0.51 0.67 < 0.01 0.43 0.07 < 0.01
Dabigatran 326750 490358 Random 0.99 0.87 1.12 < 0.01 0.08 0.06 0.88
Edoxaban 48875 81025 Random 0.62 0.44 0.87 < 0.01 1.00 0.09 < 0.01
Rivaroxaban 312311 396000 Random 1.00 0.86 1.17 < 0.01 0.58 0.06 0.97
All NOACs 930749 1368506 Random 0.78 0.58 1.06 < 0.01 0.73 0.75 0.12
  1. CI = confidence interval, HR = hazard ratio, NOACs = non-vitamin K antagonist oral anticoagulants