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The Egyptian Heart Journal
Fig. 1 | The Egyptian Heart Journal

Fig. 1

From: COVID-19 and myocarditis: a review of literature

Fig. 1

Pathophysiology of COVID-19-induced myocarditis. SARS-CoV-2 uses the Spike protein to bind to and enter a variety of cells including type II alveolar cells, cardiomyocytes and endothelial cells. Myocardial inflammation results from the combination of hypoxemia, thrombus-induced ischemia and the migration of proinflammatory cytokines and cells to the area. ACE2= angiotensin-converting enzyme 2; ARDS= acute respiratory distress syndrome; IL-6= interleukin 6; SARS-CoV-2= severe acute respiratory syndrome coronavirus 2; WBC= white blood cell

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