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Table 4 Predicted targeted genes for has-mir-194-5p (based on MANE transcript)

From: miR-454-3p and miR-194-5p targeting cardiac sarcolemma ion exchange transcripts are potential noninvasive diagnostic biomarkers for childhood dilated cardiomyopathy in Egyptian patients

Gene

MANE Transcript

Binding probability

Binding energy

AU rich region fraction

Positions

KEEG pathways

CACNA2D1

NM_000722

1

− 20.5

0.588

3′UTR

Cardiac muscle contraction (hsa04260)

CACNA1C

NM_000719

0.991452991

− 22.1

0.456

3′UTR

 

NM_001167623

0.991452991

− 22.1

0.456

3′UTR

ATP1B3

NM_001679

1

− 17.6

0.515

CDS

ATP1A1

NM_000701

1

− 21.9

0.5

CDS

RYR2

NM_001035

1

− 20.5

0.5

CDS

CACNA2D1

NM_000722

1

− 20.5

0.588

3′UTR

DCM (hsa05414)

CACNA1C

NM_000719

0.991452991

− 22.1

0.456

3′UTR

 

NM_001167623

0.991452991

− 22.1

0.456

3′UTR

TGFB2

NM_003238

1

− 23.6

0.529

3′UTR

DAG1

NM_004393

1

− 19.3

0.441

3′UTR

TTN

NM_001267550

1

− 22.8

0.515

CDS

ITGA2

NM_002203

1

− 18.3

0.691

CDS

RYR2

NM_001035

1

− 20.5

0.5

CDS

Common target genes in the used KEEG pathways

CACNA2D1, CACNA1C, RYR2

  1. It means matched annotated transcripts from refseq (NCBI) and gencode (Ensemble;EMBL-EBI)