Table 1 Effect of statin on different organs of the body
From: Pleotropic effects of statins: the dilemma of wider utilization of statin
Organ | Author | Summary |
|---|---|---|
Liver | Foster et al | Combination regimen of vitamin E 1000Â IU, vitamin C 1Â g and atorvastatin 20Â mg reduced relative risk of developing hepatic steatosis by 71% with a baseline NAFLD as compared to placebo |
Chomphupan et al | A low dose (10Â mg) of Simvastatin is helpful in preventing stroke in type-2 diabetes patients | |
Kidney | Nayan et al | Statin utilization among kidney cancer patients is linked to higher survival rates |
Nervous system | Salagre et al | If statins and anti-depressive therapy are used as combination therapy, symptoms of depression can be reduced significantly |
Jenson et al | Statins have beneficial effects in chronic inflammatory disorders like multiple sclerosis and optic neuritis | |
Bone | Nabarawi et al | Atorvastatin increase bone formation. Elevation of biomarkers of bone formation was seen in the serum. Apart from this, the bone reabsorption is also diminished |
Lin et al | Statin use was linked with a lower incidence of vertebral and hip fracture in stroke patients, and osteoporosis | |
Gupta et al | Simvastatin has the ability to reduce periodontal infection,diminsh inflammation in the temporomandibular joint, improve alveolar and periodontal bone regeneration, cartilage repair and soft tissue grafting | |
Thabit et al | Simvastatin or Atorvastatin treatment promoted bone mineral density | |
Lungs | Papaporfyriou et al | Using statins fluvastatin and atorvastatin, can lower levels of c-reactive protein, pulmonary hypertension, and mortality risk in people with COPD |
Mullerova et al | Statins may have antiviral and anti-inflammatory properties (down-regulation of cytokines) |