Predictive value of CHA2DS2VASC score for contrast-induced nephropathy after primary percutaneous coronary intervention for patients presenting with acute ST-segment elevation myocardial infarction

Samir, Ahmad; Gabra, Wafik; Alhossary, Hossam; Bakhoum, Sameh

doi:10.1186/s43044-023-00378-x

The Egyptian Heart Journal

Table 2 Baseline characteristics of the whole study group, the CIN and the No-CIN groups

From: Predictive value of CHA₂DS₂VASC score for contrast-induced nephropathy after primary percutaneous coronary intervention for patients presenting with acute ST-segment elevation myocardial infarction

	All study group (n = 500)	CIN group (n = 35)	No-CIN group (n = 465)	P value
Age (years)	54.58 ± 10.23	65.23 ± 7.24	53.77 ± 9.97	< 0.001
Male gender	425 (85%)	27 (77.14%)	398 (85.59%)	0.215
Diabetes mellitus	226 (45.2%)	23 (65.71%)	203 (43.66%)	0.013
Hypertension	284 (56.8%)	26 (74.29%)	258 (55.48%)	0.034
Dyslipidemia	460 (92.00%)	35 (100%)	425 (91.4%)	0.098
Prior stroke or TIA	10 (2.00%)	5 (14.29%)	5 (1.08%)	< 0.001
Abnormal kidney functions*	44 (8.80%)	11 (31.43%)	53 (11.4%)	0.002
Smoking	406 (81.20%)	27 (77.14%)	379 (81.51%)	0.505
NYHA III/IV	36 (7.20%)	11(31.43%)	25 (5.37%)	< 0.001
Killip class I	421 (84.2%)	16 (45.71%)	405 (87.1%)	< 0.001
Killip class II	56 (11.2%)	6 (17.14%)	50 (10.75%)	0.263
Killip class III	23 (4.6%)	13 (37.14%)	10 (2.15%)	< 0.001
Anterior STEMI	384 (76.80%)	29 (82.86%)	355 (76.34%)	0.456
Lateral STEMI	20 (4%)	0 (0%)	20 (4.30%)
Inferior STEMI	96 (19.20%)	6 (17.14%)	90 (19.3%)
Final TIMI flow II	6 (1.20%)	0 (0%)	6 (1.29%)	1.000
Final TIMI flow III	494 (98.80%)	35 (100%)	459 (98.71%)	1.000
Total ischemic time (min)^$	76.37 ± 30.38	116.57 ± 50.5	73.74 ± 29.33	< 0.001
CMV	213.26 ± 45.90	262.57 ± 48.77	209.55 ± 43.52	0.001
CMV/eGFR ratio	2.45 ± 0.97	3.92 ± 1.77	2.34 ± 0.78	< 0.001
Hematocrit	43.11 ± 5.94	42.81 ± 5.82	44.07 ± 6	0.76
RBG	144.66 ± 37.20	163.86 ± 43.57	143 ± 36.31	0.09
Baseline serum creatinine	0.91 ± 0.20	1.07 ± 0.33	0.89 ± 0.18	< 0.001
eGFR (mL/min/1/73 m²)	88.45 ± 24	69.66 ± 15.91	89.86 ± 23.91	< 0.001
LVEF	50.60 ± 8.59	48.83 ± 7.12	50.73 ± 8.67	0.169
Moderate/severe MR	18 (3.6%)	4 (11.43%)	14 (3.01%)	0.035
CHA2DS2 VASC score	2 [1, 2]	4 [4, 5]	1 [1, 2]	< 0.001
Mehran score	3 [2–5]	10 [10–14]	2 [2–5]	< 0.001

Continuous data are expressed as mean ± (standard deviation) or median [inter-quartile range] as appropriate, while categorical data are expressed as frequency (percentage)
CIN contrast-induced nephropathy, CMV contrast media volume, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, NYHA New York heart failure, RBG,random blood glucose, TIA transient ischemic attack, TIMI,thrombolysis in myocardial infarction
^*Baseline serum creatinine above the normal range (1.2 mg/dL), yet eGFR remains > 40 mL/min/1.73 m²
^$Representing time from symptoms onset to time of restoring flow in the culprit artery

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