Fig. 5
From: Rifampicin efficacy against doxorubicin-induced cardiotoxicity in mice
Heart sections histopathology (Hematoxylin and eosin, X 200). A Heart section of Control group; section showed normal contact myocardial fibers, clear nuclei, intact cell membrane, and normal cell arrangements. B Heart section of Doxorubicin group; section showing severe affection of the myocardium with dispersed myofibrils (Stars) separated by congested blood vessels (BV). The individual fibers are multinucleated (N). There were obvious myocardial cell swelling, widened muscle space of cardiac myocytes and areas of intervening edema, congestion, necrosis (*), inflammatory cell infiltration, and showed myocardial cell damage. Wide spaces are marked by the distance between arrowheads and vacuolated cytoplasm (arrow). C Heart section of Doxorubicin + Rifampicin 0.107 group; section showing moderate affection of the cardiac muscle in the form of patches of dispersed myofibrils, large pale area associated with bleeding and areas of intervening edema (Star) and individual fibers nuclear pyknosis (n). D Heart section of Doxorubicin + Rifampicin 0.214 group; section showing mild affection of the cardiac muscle in the form of less marked dispersion, edema (Star), less frequent individual fibers nuclear pyknosis (n) with congested blood vessel (BV) and most of myocardial fibers were multinucleated and running parallel to the apical basal axis