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The Egyptian Heart Journal

Table 3 Pulmonary hemodynamics of the patients studied

From: Impact of diastolic pulmonary gradient and pulmonary vascular remodeling on survival after left ventricular assist device implantation and heart transplantation

Variables

All patients

Pre-VAD DPG < 7

Pre-VAD DPG ≥ 7

P value

Pre-LVAD RHC

sPAP (mmHg)

58 (47–68)

54 (44–63)

68 (58.5–76)

 < 0.001

dPAP (mmHg)

31 (25–36)

28 (23–33)

35 (31.5–43)

 < 0.001

mPAP (mmHg)

42 (33–46)

38 (31–43)

46.5 (42–52.5)

 < 0.001

PCWP (mmHg)

26 (21–31)

25 (20–31)

27 (22.5–35)

0.182

Fick cardiac output (L/min)

3.27 (2.81–3.9)

3.26 (2.81–3.68)

3.83 (2.75–4.23)

0.33

Fick cardiac index (L/min per m2)

1.83 (1.63–2.13)

1.81 (1.63–2.08)

2.03 (1.44–2.16)

0.59

DPG (mmHg)

4 (2–7)

2 (1–4)

8 (7–10)

 < 0.001

TPG (mmHg)

13 (10–17)

11 (9–14)

18 (14.5–24)

 < 0.001

PVR (dynes-sec/cm−5)

258.15 (208.1–405.3)

235.3 (185.5–309.3)

397.5 (252.4–571.4)

 < 0.001

PVR index (dynes-sec/cm−5/m2)

511.35 (376.7–763.8)

450.8 (313.5–578.1)

819.5 (513.2–1082.8)

 < 0.001

PVR (WU)

3.66 (2.94–4.78)

3.3 (2.6–3.87)

4.84 (3.5–6.39)

 < 0.001

SVR (dynes-sec/cm−5)

1521.5 (1283.4–2018.5)

1517.3 (1264.7–1936.1)

1528.5 (1293.4–2112)

0.51

SVR index (dynes-sec/cm−5/m2)

2832.8 (2463.9–3427.5)

2823.7 (2296.2–3262.6)

3079.3 (2519.3–3967.7)

0.124

TPR (dynes-sec/cm−5)

916.01 (721–1071.9)

869.7 (700.2–1027.1)

965.2 (832.5–1753)

0.074

TPR index (dynes-sec/cm−5/m2)

1705.6 (1294.7–2017.4)

1586.1 (1271.7–1920)

1913.3 (1677.9–2666.6)

0.016

PVR/SVR ratio

0.18 (0.14–0.25)

0.16 (0.13–0.23)

0.23 (0.19–0.32)

0.002

Post-LVAD RHC

sPAP (mmHg)

41 (34–48)

37 (32.5–43)

47 (42–62)

 < 0.001

dPAP (mmHg)

21 (18–26)

19.5 (15.5–23.5)

24 (20–32)

0.012

mPAP (mmHg)

28 (24–34)

26.5 (23–31)

32 (27–42)

0.002

PCWP (mmHg)

18 (15–21)

17 (14–20)

19 (16–27)

0.038

Fick cardiac output (L/min)

4.24 (3.8–4.87)

4.22 (3.78–4.86)

4.24 (3.94–5.2)

0.45

Fick cardiac index (L/min per m2)

2.29 (1.94–2.54)

2.3 (1.97–2.5)

2.28 (1.87–2.7)

0.95

DPG (mmHg)

3 (2–5)

3 (2–5)

4 (2–7)

0.09

TPG (mmHg)

10 (8–13)

10 (8–12.5)

12 (9–16)

0.01

PVR (dynes-sec/cm−5)

168 (129.4–234.7)

158.85 (126.5–216.65)

205.1 (148.2–292.7)

0.023

PVR index (dynes-sec/cm−5/m2)

334.1 (257.1–437.1)

320.1 (223.98–422.8)

372.3 (316.4–539.5)

0.054

PVR (WU)

2.44 (1.87–3.13)

2.26 (1.81–2.91)

2.84 (2.36–3.41)

0.019

SVR (dynes-sec/cm−5)

1455.4 (1240.2–1736.3)

1440 (1215.8–1790.7)

1490.6 (1323.5–1626.02)

0.85

SVR index (dynes-sec/cm−5/m2)

2621.3 (2173.2–3141.8)

2617.8 (2158.4–3141.8)

2714.2 (2531.6–3126)

0.67

TPR (dynes-sec/cm−5)

562.8 (412.9–743.7)

529.6 (410.7–743.7)

631.8 (509.2–738.5)

0.38

TPR index (dynes-sec/cm−5/m2)

962.4 (790.3–1360)

919.9 (763.7–1283.6)

1262.4 (943.1–1575.8)

0.033

PVR/SVR ratio

0.13 (0.11–0.18)

0.12 (0.11–0.15)

0.2 (0.13–0.24)

0.026

  1. Data were presented as median with the 25th and 75th interquartiles
  2. DPG diastolic pulmonary gradient, TPG transpulmonary gradient, sPAP systolic pulmonary artery pressure, dPAP diastolic pulmonary artery pressure, mPAP mean pulmonary artery pressure, PCWP pulmonary capillary wedge pressure, PVR pulmonary vascular resistance, SVR systemic vascular resistance, TPR transpulmonary resistance, WU Wood unit
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