LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings

The Egyptian Heart Journal

Table 3 Genotype frequencies in case versus control

Genotype	N (%)			Chi-square test			Binary logistic regression
Genotype	Control	Case (CAD)	Total	χ²	Cramer’s V	p value	COR	95% CI	p value
G/G	10 (10%)	3 (3%)	13 (6.5%)	7.668	0.196	0.022	r(1) 2.5 4.5	r(1) 0.63–9.9 1.2–17.1	0.191 0.029
G/T	40 (40%)	30 (30%)	70 (35%)
T/T	50 (50%)	67 (67%)	117 (58.5%)

Bold value indicate significance p ≤ 0.050
CAD coronary artery disease, COR crude odds ratio, CI confidence interval
r(1) = reference category
This table shows a statistically significantly higher proportion of ‘T/T’ genotype among cases versus control (risk genotype). This association is of low strength (Cramer’s V lies between 0.1 and 0.3). A participant with ‘T/T’ genotype has 4.5 times higher odds to exhibit ACS versus a participant with ‘G/G’ genotype