LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings

The Egyptian Heart Journal

Table 4 SNP association with CAD (n = 200, adjusted by age and sex)

Model	Genotype	Control	Case (CAD)	AOR (95% CI)	P value	AIC	BIC
Co-dominant	T/T	50 (50%)	67 (67%)	r(1)	0.0077	243.8	260.3
	T/G	40 (40%)	30 (30%)	2.61 (0.6–11.3)
	G/G	10 (10%)	3 (3%)	5.6 (1.3–23.6)
Dominant	T/T	50 (50%)	67 (67%)	r(1)	0.0049	243.6	256.8
Dominant	T/G-G/G	50 (50%)	33 (33%)	4.2 (1.02–16.9)	0.0049	243.6	256.8
Recessive	T/T-T/G	90 (90%)	97 (97%)	r(1)	0.033	247	260.2
Recessive	G/G	10 (10%)	3 (3%)	2.45 (1.30–4.6)	0.033	247	260.2
Over-dominant	T/T-G/G	60 (60%)	70 (70%)	r(1)	0.07	248.2	261.4
Over-dominant	T/G	40 (40%)	30 (30%)	0.55 (0.29–1.06)	0.07	248.2	261.4
Log-additive	–	–	–	2.24 (1.32–3.80)	0.0019	241.8	255

Bold value indicate significance p ≤ 0.050
CAD coronary artery disease, AOR adjusted odds ratio, CI confidence interval, AIC Akaiki information criterion, BIC Bayesian information criterion
r(1) = reference category
This table shows that log-additive model is the best inheritance model (with the lowest p-value, AICC, and BIC). Participants with ‘T’ allele have 2.2 times higher odds adjusted for age and sex to exhibit CAD compared to participant with ‘G’ allele