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Table 5 Association of rs1122608 genotype and severity of CAD patients

From: LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings

Cases

GG

GT

TT

P

n = 3

n = 30

n = 67

EF (%)

57 ± 9.5

58 ± 12.5

55.4 ± 10.8

0.816

ECG

Average

1 (33.3%)

18 (60%)

37 (55.2%)

0.682

Abnormal

2 (66.7%)

12 (40%)

30 (44.8%)

Uni vessel

 N = 57

2 (3.5%)

18(31.6%)

37 (64.9%)

0.378

Two vessels

 N = 31

1 (3.2%)

11 (35.5%)

19 (61.3%)

More than two vessels

 N = 12

0 (0.0%)

1 (8.3%)

11 (91.7%)

Gensini score

26.7 ± 19.7

32 ± 30.1

34.4 ± 29.5

0.863

  1. This table reveals no significant differences found regarding ejection fraction (EF), electrocardiograph (ECG) among rs1122608 genotypes in CAD group (p = 0.816, 0.682 respectively), no significant association is found between rs1122608 genotypes and alleles with extent of vessel affection (p = 0.378), in spite of increased frequency of TT genotype in CAD patients with multi-vessel affection more than those with one vessel and two vessel affected (91.7%, 61.3%, 64.9% respectively). As regard Gensini score, it shows no significant association with rs1122608 genotypes (p = 0.863)