Table 1 Troponin I and BNP levels as prognostic biomarkers in carbon monoxide poisoning—summary of key findings
Author | Patel et al. [21] | Koga et al. [17] | Ashry et al. [49] | Turan et al. [50] |
|---|---|---|---|---|
Gender | 58.8% males, 35.3% non-White | 42 men, 28 women | Male: 29 (69%) Female: 13 (31%) | Male gender, younger age |
Mean age | 51.2 | 52 ± 18 | 27.1 ± 12.2 | Children aged 0–17 years |
Study design | Observational study | Retrospective study | Observational study | Observational study |
Study period | 1 January 2012 and 31 August 2019 | June 2013 and September 2019 | December 2016 and May 2017 | October 2017 and April 2019 |
Study population | 119 patients with CO poisoning | 70 patients with CO poisoning | 42 patients with acute CO poisoning | Children with CO poisoning |
Troponin Level | Used as a predictor | Used as a predictor | Not mentioned | Not mentioned |
BNP Level | Not mentioned | Not mentioned | Used as a predictor | Used as a predictor |
Key Findings | 22 patients (18.5%) experienced myocardial damage, which was linked to a higher risk of intubation and critical care unit hospitalization | Based on the corrected QT dispersion and the troponin I level, it is possible to estimate the prognosis of patients after CO poisoning | BNP levels are elevated in individuals with acute CO poisoning | A higher NT-proBNP level (> 480 pg/ml) might be a valuable biomarker for the early identification of myocardial damage caused by carbon monoxide |
Conclusions | Elevation of TnI was linked to increased mortality inside hospitals | Patients with myocardial injury should have their prognosis and neurological and cardiovascular outcomes examined in addition to their cardiovascular outcomes | A precise, trustworthy biomarker of cardiac damage in patients suffering from acute CO poisoning may be plasma BNP levels | When left ventricular ejection fraction is decreased and myocardial damage brought on by carbon monoxide is present, NT-proBNP may be helpful in detecting it early |