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The Egyptian Heart Journal

Table 4 The descriptive data, clinical, ECG, echocardiographic, CT parameters comparison between group A and the extreme oversizing group B

From: Impact of prosthesis oversizing on clinical outcomes of transcatheter aortic valve implantation using a self-expandable Evolut R valve

Demographics &clinical data

Group A (< 20%)

Group B (≥ 20%)

Test value

P-value

Sig.

No. = 97

No. = 46

Age (years)

Female

39 (40.2%)

21 (45.7%)

0.380*

0.538

NS

 

Male

58 (59.8%)

25 (54.3%)

Weight (kg)

Mean ± SD

74.33 ± 7.05

72.70 ± 5.24

1.398•

0.164

NS

 

Range

  

Height (m)

Mean ± SD

55–88

62–86

0.697•

0.487

NS

 

Range

50–115

50–125

BMI(kg/m2)

Mean ± SD

1.65 ± 0.08

1.63 ± 0.07

1.697•

0.092

NS

 

Range

1.5–1.82

1.5–1.8

BSA (m2)

Mean ± SD

28.86 ± 5.28

29.53 ± 4.98

 − 0.727•

0.468

NS

 

Range

18.82–47.87

21.8–41.52

Age (years)

Mean ± SD

1.88 ± 0.17

1.86 ± 0.19

0.479•

0.633

NS

 

Range

1.44–2.25

1.52–2.39

CABG

No

86 (88.7%)

44 (95.7%)

1.846*

0.174

NS

 

Yes

11 (11.3%)

2 (4.3%)

Euro score II %

Median (IQR)

3.56 (2.28–6.18)

2.97 (1.54–3.89)

 − 2.358‡

0.018

S

 

Range

0.84–40.2

0.92–8.12

STS score %

Median (IQR)

2.58 (1.81–3.88)

2.26 (1.57–2.87)

 − 2.066‡

0.039

S

 

Range

0.66–16.98

0.99–7.08

Smoking

Non-smoker

71 (73.2%)

36 (78.3%)

0.960*

0.619

NS

 

Smoker

19 (19.6%)

6 (13.0%)

 

EX -smoker

7 (7.2%)

4 (8.7%)

DM

No

51 (52.6%)

24 (52.2%)

0.002*

0.964

NS

 

Yes

46 (47.4%)

22 (47.8%)

HTN

No

23 (23.7%)

10 (21.7%)

0.068*

0.794

NS

 

Yes

74 (76.3%)

36 (78.3%)

RHD

No

94 (96.9%)

42 (91.3%)

2.104

0.147

NS

 

Yes

3 (3.1%)

4 (8.7%)

IHD

No

54 (55.7%)

33 (71.7%)

3.382*

0.066

NS

 

Yes

43 (44.3%)

13 (28.3%)

CVS

No

91 (93.8%)

43 (93.5%)

0.006*

0.938

NS

 

Yes

6 (6.2%)

3 (6.5%)

CrCl (ml/min)

Mean ± SD

61.20 ± 24.39

68.22 ± 30.85

 − 1.473•

0.143

NS

 

Range

9–134.07

15–161

CLD

No

89 (91.8%)

43 (93.5%)

0.131*

0.718

NS

 

Yes

8 (8.2%)

3 (6.5%)

ECG

Group A (< 20%)

Group B (≥ 20%)

Test value

P-value

Sig.

 

No. = 97

No. = 46

AF

No

80 (82.5%)

37 (80.4%)

0.303*

0.859

NS

 

Permanent

11 (11.3%)

5 (10.9%)

 

Paroxysmal

6 (6.2%)

4 (8.7%)

PR (ms)

Mean ± SD

163.33 ± 37.09

159.76 ± 34.24

0.521•

0.603

NS

 

Range

0–200

80–200

QRS (ms)

Mean ± SD

89.38 ± 9.55

87.17 ± 9.11

1.310•

0.192

NS

 

Range

80–110

80–100

Echo

Group A (< 20%)

Group B (≥ 20%)

Test value

P-value

Sig.

 

No. = 97

No. = 46

EF(%)

Mean ± SD

59.33 ± 13.58

62.17 ± 12.09

 − 1.207•

0.229

NS

 

Range

20–84

25–78

   

SWT (mm)

Mean ± SD

12.73 ± 1.64

12.45 ± 2.04

0.862•

0.390

NS

 

Range

8–17

8–18

   

SWTi (mm/m2)

Mean ± SD

6.76 ± 1.23

6.70 ± 1.04

0.285•

0.776

NS

 

Range

0.51–9.8

4.79–8.94

   

PWT (mm)

Mean ± SD

12.39 ± 1.49

11.95 ± 1.87

1.519•

0.131

NS

 

Range

8–16

7–16

   

PWTi(mm/m2)

Mean ± SD

6.59 ± 1.20

6.42 ± 0.96

0.796•

0.428

NS

 

Range

0.51–9.8

4.29–8.33

   

LVEDD(mm)

Mean ± SD

50.58 ± 7.02

49.87 ± 5.56

0.604•

0.547

NS

 

Range

35–74

39–64

   

LVEDDi (mm/m2)

Mean ± SD

26.86 ± 5.23

26.94 ± 3.62

 − 0.097•

0.923

NS

 

Range

0.51–46.54

19.7–36.99

   

LVESD(mm)

Mean ± SD

33.71 ± 7.59

32.72 ± 7.32

0.737•

0.463

NS

 

Range

20–63

20–51

   

LVESDi(mm/m2)

Mean ± SD

17.99 ± 4.88

17.67 ± 4.47

0.379•

0.705

NS

 

Range

0.51–37.73

11.08–29.48

   

PPG(mmHg)

Mean ± SD

81.99 ± 20.88

81.48 ± 23.80

0.129•

0.897

NS

 

Range

38–171

35–145

   

MPG (mmHg)

Mean ± SD

50.45 ± 13.59

49.09 ± 14.33

0.549•

0.584

NS

 

Range

20–100

25–90

   

AVA (cm2)

Median (IQR)

0.7 (0.5–0.8)

0.7 (0.5–0.8)

 − 0.513‡

0.608

NS

 

Range

0.2–1

0.3–8

   

AVAi (cm2/m2)

Mean ± SD

0.37 ± 0.11

0.38 ± 0.11

 − 0.405•

0.686

NS

 

Range

0.1–0.59

0.17–0.59

   

AR

0

12 (12.4%)

3 (6.5%)

3.036*

0.552

NS

 

1

54 (55.7%)

32 (69.6%)

   
 

2

28 (28.8%)

10 (21.7%)

   
 

3

3 (3.1%)

1 (2.2%)

   
 

4

0 (0.0%)

0 (0.0%)

   

RVSP (mmHg)

Mean ± SD

42.47 ± 10.96

41.04 ± 11.16

0.721•

0.472

NS

 

Range

25–77

20–86

CT

Annulus. Diameter (mm)

Mean ± SD

24.49 ± 1.69

23.49 ± 1.63

3.344

0.001

HS

Annulus. Diameter.indexed (mm/m2)

Mean ± SD

13.13 ± 1.44

12.69 ± 1.27

1.774

0.078

NS

Annulus. Perimeter (mm)

Mean ± SD

79.06 ± 4.62

75.67 ± 5.31

3.910

0.000

HS

Annulus. Perimeter. Indexed (mm/m2)

Mean ± SD

42.38 ± 4.35

40.88 ± 4.14

1.954

0.053

NS

Annulus. Area (mm2)

Mean ± SD

474.14 ± 59.63

432.15 ± 60.36

3.890

0.000

HS

Annulus. Area indexed (mm2/m2)

Mean ± SD

253.93 ± 37.41

233.39 ± 33.69

3.137

0.002

HS

LMCA (mm)

Mean ± SD

12.89 ± 2.78

13.10 ± 2.24

 − 0.448

0.655

NS

LMCAi (mm/m2)

Mean ± SD

6.91 ± 1.62

7.07 ± 1.26

 − 0.578

0.564

NS

RCA (mm)

Mean ± SD

14.95 ± 3.26

14.95 ± 2.75

 − 0.003

0.998

NS

RCAi (mm/m2)

Mean ± SD

8.04 ± 2.02

8.11 ± 1.77

 − 0.207

0.837

NS

MS (mm)

Mean ± SD

8.91 ± 2.14

8.63 ± 1.86

0.765

0.445

NS

MS I (mm/m2)

Mean ± SD

4.80 ± 1.32

4.69 ± 1.18

0.453

0.651

NS

Grade of aortic calcification

Grade 1

0 (0.0%)

1 (2.2%)

9.820*

0.020

S

 

Grade 2

17 (17.5%)

7 (15.2%)

   
 

Grade 3

33 (34.0%)

26 (56.5%)

   
 

Grade 4

47 (48.5%)

12 (26.1%)

   

Severe or non severe aortic calcification

Grade 1–3

50 (51.5%)

34 (73.9%)

6.441*

0.011

S

 

Grade 4

47 (48.5%)

12 (26.1%)

   

Septal calcification

No

81 (83.5%)

42 (91.3%)

1.578*

0.209

NS

 

Yes

16 (16.5%)

4 (8.7%)

   
  1. AF Atrial fibrillation, AR Aortic regurgitation, AVA Aortic valve area, AVAi Aortic valve area indexed, BMI Body mass index, BSA Body surface area, Ca Calcification, CABG Coronary artery bypass graft, CLD Chronic lung disease, CrCl Creatinine clearance, CVS Cerebrovascular stroke, DM Diabetes mellitus, EF Ejection fraction, HTN Hypertension, IHD Ischemic heart disease, LVEDD Left ventricle end diastolic dimension, LVEDDi Left ventricle end diastolic dimension indexed, LVESD Left ventricle end systolic dimension, LVESDi Left ventricle end systolic dimension indexed, LMCA Left main coronary artery height, LMCAi Left main coronary artery height indexed, MPG Mean pressure gradient, MS Membranous septum, MSi Membranous septum indexed, PWT Posterior wall thickness, PWTi Posterior wall thickness indexed, PPG Peak pressure gradient, RCA Right coronary artery height, RCAi Right coronary artery height indexed, RHD Rheumatic heart disease, RVSP Right ventricular systolic pressure, STS PROM Society of thoracic surgery predicted risk of mortality, SWT Septal wall thickness, SWTi Septal wall thickness indexed
  2. P-value > 0.05: Non significant (NS); P-value <0.05: Significant (S); P-value< 0.01: highly significant (HS)
  3. ‡Mann Whitney test, *Chi-square test, •Independent t-test
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