Table 2 Epinephrin, from discovery of adrenal gland and isolation of the hormone, till synthetization as a drug and providing indications
Date | Event |
|---|---|
1564 | Bartolomeo Eustachio, anatomist, was the first to describe the adrenal gland [42] |
1855 | Thomas Addison described 10 cases with the clinical syndrome of adrenal insufficiency [43] |
1894 | Oliver and Schafer demonstrated the hormonal pressor effect of the adrenal extract, this was on Saturday, March 10, which was a day of note for medicine [44] |
1899 | Abel published a paper announcing an extract which he named “epinephrin” (the Greek word, epi, means “close by,” while nephros, “kidney”) [45] |
1900 | Takamine and Uenaka visited Parke, Davis & Co. for the full-scale production of adrenalin at the factory level. Coining the Name “Adrenalin” the Latin word “ad” means “near” while “renal” means “kidney,” and Patent Application [46] |
1903 | George Crile a surgeon who discovered the most important role for adrenaline in surgical shock [47] and cardiac arrest [48] |
1903 | Bullowa and Kaplan had described the successful treatment of asthmatics with subcutaneous injections of adrenaline [49] |
1919 | Harris Boughton reviewed a number of deaths in asthmatics with known allergies to horses and reported adrenaline use in anaphylaxis [50] |
1923 | Carl Bodon published a review of the use of intracardiac drugs including adrenaline [51] |
1956 | Green et al. reported the experimental finding that circulating ferritin inhibit the vasoconstrictor response to adrenaline [40] |
2020 | Jacic, Jelena Korac et al. Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors [41] |
2023 | Clinical report of reducing ferritin level by epinephrin which may attenuate cytokine storm by inhibiting ferroptosis |