Association between homocysteine and coronary artery disease—trend over time and across the regions: a systematic review and meta-analysis

The Egyptian Heart Journal

Table 3 Certainty of evidence on the association between the homocysteine and CAD by GRADE profile

No. of studies	Risk of bias	Inconsistency	Indirectness	Imprecision	Publication bias	Summary findings			Certainty of evidence
No. of studies	Risk of bias	Inconsistency	Indirectness	Imprecision	Publication bias	Casesn	Controln	SMD (95% CI)	Certainty of evidence
59	No serious limitations	Serious limitations	No serious limitations	No serious imprecision	Serious limitations	9381	12,188	0.73 (0.55–0.91)	⊕ ⊕ OO LOW