Table 4 ECG parameters prior to and following the start of the sacubitril/valsartan combination
Before S/V therapy | Six months after S/V therapy | Test value | p-value | |
|---|---|---|---|---|
HR(bpm) | ||||
Mean ± SD | 78.14 ± 9.98 | 73.05 ± 7.64 | − 5.394** | 0.000 |
Rhythm | ||||
Sinus | 77/100 (77.0%) | 71/100 (71.0%) | 2.563* | 0.278 |
hy | ||||
AF | 23/100 (23.0%) | 27/100 (27.0%) | ||
PR interval (ms) | ||||
Mean ± SD | 138.53 ± 26.72 | 137.11 ± 24.20 | − 0.541** | 0.590 |
QRS width | ||||
Mean ± SD | 123.70 ± 20.32 | 117.05 ± 18.79 | − 6.435** | 0.000 |
QTc | ||||
Mean ± SD | 425.37 ± 32.86 | 421.35 ± 32.32 | − 2.573** | 0.012 |
T wave morphology | ||||
Normal | 11/100 (11.0%) | 11/100 (11.0%) | 2.737* | 0.603 |
Inverted T | 64/100 (64.0%) | 67/100 (67.0%) | ||
Flat T | 10/100 (10.0%) | 9/100 (9.0%) | ||
Biphasic T | 15/100 (15.0%) | 11/100 (11.0%) | ||
ST segment | ||||
Normal | 12 (12.0%) | 19 (19.0%) | 4.693* | 0.196 |
Depressed ST | 73 (73.0%) | 69 (69.0%) | ||
Elevated ST | 15 (15.0%) | 10 (10.0%) | ||