Left ventricular diastolic function and cardiotoxic chemotherapy

The Egyptian Heart Journal

Table 2 Baseline and follow-up echocardiographic parameters

Parameter	Baseline	At 3 months	At 6 months	P value (*)	P value (**)
Parameter	Mean ± SD	Mean ± SD	Mean ± SD	P value (*)	P value (**)
Ejection fraction	64.92 ± 1.96	64.44 ± 1.56	60.97 ± 4.94	0.08	P = 0.0001
E/A	1.36 ± 0.138	1.20 ± 0.343	1.11 ± 0.333	0.0002	P = 0.0001
DT (ms)	179.62 ± 8.92	185.23 ± 11.21	196.14 ± 41.94	0.0006	P = 0.0001
IVRT (ms)	86.92 ± 4.53	91.82 ± 6.54	94.04 ± 10.70	0.0001	P = 0.0001
e′ septal	10.6 ± 0.83	9.58 ± 1.06	8.58 ± 2.07	0.0001	P = 0.0001
e ‘lateral	14.01 ± 0.806	12.04 ± 1.96	10.90 ± 2.96	0.0001	P = 0.0001
E/e′ septal	8.66 ± 1.085	9.01 ± 0.645	9.21 ± 0.731	0.01	P = 0.0002
Peak TR velocity m/s	2.12 ± 0.287	2.20 ± 0.590	2.22 ± 0.390	0.27	P = 0.06
LAVI (ml/BSA)	21.59 ± 2.29	21.89 ± 2.25	24.56 ± 2.15	0.34	0.001
GLS	− 18.81 ± 0.797	− 18.26 ± 1.7	− 17.65 ± 2.057	0.009	P = 0.0001

E mitral inflow early diastolic velocity; A mitral inflow late diastolic velocity; DT deceleration time; IVRT isovolumic relaxation time; e′ mitral annular early tissue Doppler velocity; TR tricuspid regurgitation; GLS global longitudinal strain; LAVI (ml/BSA) left atrial volume index/body surface area
P* = P value between baseline and three months
P** = P value between baseline and at 6 months