Table 1 Event probabilities, cost, hazard ratio, and utility used in the model

drC

0.03

Discounting rate for costs

WHO 2015

drO

0.03

Discounting rate for outcomes

WHO 2015

Transitional probabilities

tpRA_RA

0.952

Transition probability from Resolved ACS to Stay Resolved ACS

0.095

tpRA_MI

0.012

Transition probability from RA to MI

0.001

Taylor et al. [19]

tpRA_CAr

0.001

Transition probability from RA to Cardiac Arrest

0.001

Taylor et al. [19]

tpRA_Rv

0.035

Transition probability from RA to Revascularization

0.001

Taylor et al. [19]

tpMI_MI

0.049

Transition probability from MI to MI

0.010

Taylor et al. [19]

tpMI_Rv

0.027

Transition probability from MI to Revascularization

0.004

Taylor et al. [19]

tpMI_D_30to34

0.007

Transition probability from MI to Death age 30–34

0.001

Taylor et al. [19]

tpMI_D_35to39

0.009

Transition probability from MI to Death age 35–39

0.001

Taylor et al. [19]

tpMI_D_40to44

0.014

Transition probability from MI to Death age 40–44

0.001

Taylor et al. [19]

tpMI_D_45to49

0.020

Transition probability from MI to Death age 45–49

0.002

Taylor et al. [19]

tpMI_D_50to54

0.032

Transition probability from MI to Death age 50–54

0.003

Taylor et al. [19]

tpMI_D_55to59

0.050

Transition probability from MI to Death age 55–59

0.005

Taylor et al. [19]

tpMI_D_60to64

0.084

Transition probability from MI to Death age 60–64

0.008

Taylor et al. [19]

tpMI_D_65to69

0.131

Transition probability from MI to Death age 65–69

0.013

Taylor et al. [19]

tpMI_D_70to74

0.205

Transition probability from MI to Death age 70–74

0.021

Taylor et al. [19]

tpMI_D_75to79

0.326

Transition probability from MI to Death age 75–79

0.033

Taylor et al. [19]

tpMI_D_80to84

0.508

Transition probability from MI to Death age 80–84

0.051

Taylor et al. [19]

tpCAr_D_30to34

0.004

Transition probability from Cardiac Arrest to Death age 30–34

0.000

Taylor et al. [19]

tpCAr_D_35to39

0.005

Transition probability from Cardiac to Death age 35–39

0.001

Taylor et al. [19]

tpCAr_D_40to44

0.008

Transition probability from Cardiac Arrest to Death age 40–44

0.001

Taylor et al. [19]

tpCAr_D_45to49

0.012

Transition probability from Cardiac Arrest to Death age 45–49

0.001

Taylor et al. [19]

tpCAr_D_50to54

0.018

Transition probability from Cardiac Arrest to Death age 50–54

0.002

Taylor et al. [19]

tpCAr_D_55to59

0.028

Transition probability from Cardiac Arrest to Death age 55–59

0.003

Taylor et al. [19]

tpCAr_D_60to64

0.048

Transition probability from Cardiac Arrest to Death age 60–64

0.005

Taylor et al. [19]

tpCAr_D_65to69

0.074

Transition probability from Cardiac Arrest to Death age 65–69

0.007

Taylor et al. [19]

tpCAr_D_70to74

0.116

Transition probability from Cardiac Arrest to Death age 70–74

0.012

Taylor et al. [19]

tpCAr_D_75to79

0.185

Transition probability from Cardiac Arrest to Death age 75–79

0.019

Taylor et al. [19]

tpCAr_D_80to84

0.288

Transition probability from Cardiac Arrest to Death age 80–84

0.029

Taylor et al. [19]

tpRv_Rv

0.135

Transition probability from Revascularization to Revascularization

0.009

Taylor et al. [19]

tpRv_MI

0.396

Transition probability from Revascularization to MI

0.024

Taylor et al. [19]

tpRv_D_30to34

0.004

Transition probability from Revascularization to Death age 30–34

0.000

Taylor et al. [19]

tpRv_D_35to39

0.005

Transition probability from Revascularization to Death age 35–39

0.001

Taylor et al. [19]

tpRv_D_40to44

0.007

Transition probability from Revascularization to Death age 40–44

0.001

Taylor et al. [19]

tpRv_D_45to49

0.011

Transition probability from Revascularization to Death age 45–49

0.001

Taylor et al. [19]

tpRv_D_50to54

0.017

Transition probability from Revascularization to Death age 50–54

0.002

Taylor et al. [19]

tpRv_D_55to59

0.027

Transition probability from Revascularization to Death age 55–59

0.003

Taylor et al. [19]

tpRv_D_60to64

0.045

Transition probability from Revascularization to Death age 60–64

0.005

Taylor et al. [19]

tpRv_D_65to69

0.071

Transition probability from Revascularization to Death age 65–69

0.007

Taylor et al. [19]

tpRv_D_70to74

0.111

Transition probability from Revascularization to Death age 70–74

0.011

Taylor et al. [19]

tpRv_D_75to79

0.176

Transition probability from Revascularization to Death age 75–79

0.018

Taylor et al. [19]

tpRv_D_80to84

0.274

Transition probability from Revascularization to Death age 80–84

0.027

Taylor et al. [19]

Cost parameters

Direct Costs per Health State

dmcRA

Rp 19,728,100

Direct medical costs associated with Resolved ACS

Rp 197,281

INA-CBGs 2016

dmcMI

Rp 12,118,800

Direct medical costs associated with Myocardial Infarction

Rp 121,188

INA-CBGs 2016

dmcCAr

Rp 7,041,400

Direct medical costs associated with Cardiac Arrest

Rp 70,414

INA-CBGs 2016

dmcRv

Rp 40,024,100

Direct medical costs associated with Revascularization

Rp 400,241

INA-CBGs 2016

Cost of Interventions

cHIS

Rp 3,908,568.00

Direct Medical Cost of using High-Intensity Statin per year

Rp 390,856.80

Indonesia Secondary Hospital Type B

cNHIS

Rp 1,474,656.00

Direct Medical Cost of using Moderate Statin per year

Rp 147,465.60

Indonesia Secondary Hospital Type B

High-Intensity Statin Efficacy

HR_HIS_MI

0.77

HR for MI events by using HIS

0.07

Taylor et al. [19]

HR_HIS_CAr

1.07

HR for Cardiac Arrest events by using HIS

0.11

Taylor et al. [19]

HR_HIS_Rv

0.73

HR for Revascularization events by using HIS

0.04

Taylor et al. [19]

Utility parameters

uRA

0.78

Quality of life for Resolved ACS

0.078

Lin et al. [20]

uMI

0.65

Quality of life for Myocardial Infarction

0.065

Lin et al. [20]

uCAr

0.68

Quality of life for Cardiac Arrest

0.068

Lin et al. [20]

uRv

0.78

Quality of life for Revascularization

0.078

Taylor et al. [19]