Table 1 Characteristics of the included studies

Franchi F, 2023^*

Patients with coronary artery disease

 > 18

20

(9:11)

Measurement of PRU at different time points

30 mcg/kg bolus

followed by

4 mcg/kg/min

Ticagrelor (180 mg loading dose)

Buchtele, 2020^*

Adult survivors of out-of-hospital cardiac arrest with ST-segment elevation myocardial infarction (STEMI)

 > 18

16

(13:3)

Rate of high platelet reactivity at different time points

30 mcg/kg bolus

followed by

4 mcg/kg/min

Ticagrelor (180 mg oral loading dose of crushed ticagrelor)

Rossini, 2020^*

Patients with previous PCI who were still on DAPT and undergoing nondeferrable surgery requiring DAPT discontinuation

 > 18

24

(19:5)

Measurement of PRU at different time points

0.75 μg/kg/min infusion without a bolus

Ticagrelor

( 90 mg BD)

Mohammed, 2017^*

STEMI patients undergoing primary PCI

 > 18

32

(22:10)

Measurement of PRU at different time points

30 mcg/kg bolus followed by 4 mcg/kg/min

Ticagrelor (loading dose of 180 mg oral)

Franchi F, 2019^#

STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

 > 18

50

(37:13)

Measurement of PRU at different time points

30 mcg/kg bolus followed by 4 mcg/kg/min

Ticagrelor

(180-mg Loading dose of ticagrelor)

Ubaid S, 2019^#

STEMI undergoing primary PPCI

 > 18

100

(72:28)

Measurement of PRU at different time points

30 mcg/kg bolus followed by 4 mcg/kg/min

Ticagrelor (loading dose of 180 mg)

Scalia L, 2022^#

STEMI undergoing primary PPCI

 > 18

396

Composite of all-cause death, myocardial infarction (MI), definite or probable stent thrombosis and unplanned repeat revascularization within hospital discharge

30 mcg/kg bolus followed by 4 mcg/kg/min

Ticagrelor (loading dose of 180 mg)

Badreldin, 2017^#

Patients undergoing PPCI

 > 18

124

(84:40)

In hospital all-cause mortality and stent thrombosis

30 mcg/kg bolus followed by 4 mcg/kg/min

Ticagrelor (loading oral dose of 180 mg)