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Table 1 Risk categories and LDL-C goals

From: Egyptian practical guidance in lipid management 2020

Cardiovascular risk categories LDL-C goal
Very high risk 1. Atherosclerotic cardiovascular disease (ASCVD) (clinical or imaging)
2. SCORE equal to or more than 10%
3. Family history of ASCVD or any major risk factor
4. Severe chronic kidney disease (estimated glomerular filtration rate < 30 mL/min)
5. Diabetes mellitus and or target organ damage: ≥ 3 major risk factors; or early onset of type 1 diabetes mellitus and long duration (> 20 years)
< 55 mg/dL
High risk 1. SCORE ≥ 5% and < 10%
2. Markedly elevated single risk factors, in particular TC > 310 mg/dL or LDL-C > 190 mg/dL or BP ≥ 180/110 mmHg
3. FH without other major risk factors
4. Moderate CKD (eGFR 30–59 mL/min)
5. DM without target organ damage, with DM duration ≥10 years or other additional risk factors
< 70 mg/dL
Moderate risk 1. SCORE equal or more than 1% and less than 5%
2. Young diabetic patients (type 1 < 35 years, type 2 < 50 years) with diabetes duration < 10 years in absence of other risk factors
< 100 mg/dL
Low risk 1. SCORE < 1% < 116 mg/dL